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Accession IconGSE40793

Conversion of human fibroblasts into vascular cells (gene expression)

Organism Icon Homo sapiens
Sample Icon 25 Downloadable Samples
Technology Badge IconIllumina HumanHT-12 V3.0 expression beadchip

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Description
We report a novel technique to reprogram human fibroblasts into endothelial and smooth muscle cells using partial iPSC reprogramming and chemically defined media. Using appropriate media conditions for differentiation of human pluripotent cells to CD34+ vascular progenitor cells, we show that temporary expression of pluripotent transcription factors and treatment with chemically-defined media, will induce differentiation of human fibroblasts to CD34+ vascular progenitor cells. Sorted CD34+ cells can then be directed to differentiate into vascular endothelial cells expressing a variety of smooth muscle markers.
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