Expression data from E18.5 mouse dorsal telencephalon

Radial progenitors deficient in both Mek1 and Mek2 fail to transition to the gliogenic mode in late embryogenesis, and astrocyte and oligodendroglial precursors fail to appear. In exploring mechanisms, we found the Ets transcription family member Etv5/Erm is strongly regulated by MEK. Our microarray assay showed that Erm is specifically downregulated in Mek mutant brain.

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Li X, Newbern JM, Wu Y, Morgan-Smith M, Zhong J, Charron J, Snider WD