Gene expression characterization of HPV positive head and neck cancer to predict response to Chemoradiation

Background: Human papillomavirus has been shown to have a causal role in the development of head and neck squamous cell carcinoma and represents a distinct and well-defined pathology. While HPV-positive HNSCC is associated with a better response to treatment and prognosis, a subset of patients do not respond favorably to current standard of care thus suffering unnecessary morbidity and delay to receive effective therapy.

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Thibodeau BJ, Geddes TJ, Fortier LE, Ahmed S, Pruetz BL, Wobb J, Chen P, Wilson GD, Akervall JA