Hepatic gene expression in streptozotocin-induced diabetic mice fed a phloridzin diet

Phloridzin is a dihydrochalcone typically contained in apples. A diet containing 0.5 % phloridzin significantly improves hyperglycemia but not hypoinsulinemia and tissue lipid peroxidation in streptozotocin (STZ)-induced diabetic mice after 14 days. The phloridzin diet has no effect on the alteration of hepatic gene expression in STZ-induced diabetic mice.

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Masumoto S, Akimoto Y, Oike H, Kobori M