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Accession IconGSE37450

Molecular Phenotyping of Immune Cells from Young NOD Mice

Organism Icon Mus musculus
Sample Icon 60 Downloadable Samples
Technology Badge Icon Affymetrix Mouse Expression 430A Array (moe430a), Affymetrix Mouse Expression 430B Array (moe430b)

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Description
Islet leukocytic infiltration (insulitis) is first obvious at around 4 weeks of age in the NOD mouse a model for human type 1 diabetes (T1DM). The molecular events leading to insulitis are poorly understood. Since TIDM is caused by numerous genes, we hypothesized that multiple molecular pathways are altered and interact to initiate this disease.
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