github link
Accession IconGSE36067

Role of microRNAs in compensatory b-cell mass expansion associated with pregnancy and obesity

Organism Icon Rattus norvegicus
Sample Icon 6 Downloadable Samples
Technology Badge Icon Affymetrix Rat Gene 1.0 ST Array (ragene10st)

Submitter Supplied Information

Description
We found that in rodents, b-cell mass expansion during pregnancy and obesity is associated with changes in the expression of a group of islet microRNAs. We were able to reproduce in isolated pancreatic islets the decrease of miR-338-3p level observed in gestation and obesity by activating the G-protein coupled estrogen receptor GPR30 and the GLP1 receptor. Blockade of miR-338-3p in b-cells using specific anti-miR molecules mimicked gene expression changes occurring during b-cell mass expansion and resulted in increased proliferation and improved survival both in vitro and in vivo. These findings point to a major role for miR-338-3p in compensatory b-cell mass expansion occurring under different insulin resistance states.
PubMed ID
Total Samples
14
Submitter’s Institution

Samples

Show of 0 Total Samples
Filter
Add/Remove
Accession Code
Title
Sex
Specimen part
Cell line
Processing Information
Additional Metadata
No rows found
Loading...