Analysis of RPE65 loss of function in mouse retina

To characterize gene response in RPE65-/- mouse model of Lebers congenital amaurosis during progression of the disease, we analyzed differential gene expression in retinae early in the development of the disease, namely before and at the onset of photoreceptor cell death in knock-out mice of 2, 4 and 6 months of age.

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Cottet S, Michaut L, Boisset G, Schlecht U, Gehring W, Schorderet DF