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Accession IconGSE31411

Inter-strain Heterogeneity in Responses to TCDD

Organism Icon Rattus norvegicus
Sample Icon 56 Downloadable Samples
Technology Badge Icon Affymetrix Rat Genome 230 2.0 Array (rat2302), Affymetrix Rat Expression 230A Array (rae230a)

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Description
We profiled hepatic transcriptional responses of 6 strains of rats with varying sensitivity to a dioxin, TCDD, at 19 hours following exposure. The resistant rats exhibited significantly reduced transcriptional responses in comparison to the sensitive strains. We hypothesize that genes which show differential changes between the resistant and sensitive rats may potentially explain sensitivity.
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