The human Ewing's Sarcoma oncoprotein EWS-FLI1 causes developmental defects in zebrafish embryos

GSE31185

Danio rerio

6 Downloadable Samples

Affymetrix Zebrafish Genome Array (zebrafish)

Submitter Supplied Information

Description

The fusion oncoprotein EWS-FLI1 arises from a t(11;22)(q24;q12) chromosomal translocation and causes Ewing's Sarcoma, a malignant bone tumor. The mechanism whereby EWS-FLI1 transforms cells is unknown. We made germline transgenic zebrafish expressing human EWS-FLI1 under the control of the heat shock promoter. Induction of EWS-FLI1 expression causes multiple defects in embryonic development.

PubMed ID

21979944

Publication Title

A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis.

Total Samples

Submitter’s Institution

University of Texas Southwestern Medical Center

Authors

Leacock SW, Basse AN, Chandler GL, Kirk AM, Rakheja D, Amatruda JF

Source Repository

Gene Expression Omnibus (GEO)

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