Transgenic overexpression of Tcfap2c/AP-2gamma results in liver steatosis

We established a mouse model, in which transcription factor Tcfap2c can be activated in an inducible and reversible manner in somatic tissues, taking advantage of the tetracycline-dependent regulatory system.

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Holl D, Kuckenberg P, Woynecki T, Egert A, Becker A, Huss S, Stabenow D, Zimmer A, Knolle P, Tolba R, Fischer HP, Schorle H