Global gene expression analysis of six cadmium-transformed UROtsa cell isolates

The immortalized human urothelial cell line, UROtsa, was transformed in six parallel cultures with continual passaging in1 M Cd+2 until the cells were able to attain the ability to form colonies in soft agar and subcutaneous tumors in nude mice. The gene expression profiles between cadmium-transformed and control samples were compared and the differentially expressed genes were identified.

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Somji S, Zhou XD, Mehus A, Sens MA, Garrett SH, Lutz KL, Dunlevy JR, Zheng Y, Sens DA