Human Beta-Defensin 3 attenuates the pro-inflammatory effects of KDO2-Lipid A (KLA) at 6 hour

GSE25871

Mus musculus

12 Downloadable Samples

Illumina MouseRef-8 v2.0 expression beadchip

Submitter Supplied Information

Description

We examine the global effect of hBD3 on transcription in TLR4-stimulated macrophages and for the first time show that hBD3 inhibits the transcription of critical pro-inflammatory genes.

PubMed ID

21809339

Publication Title

Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF.

Total Samples

Submitter’s Institution

University of Edinburgh, The Institute of Genetics and Molecular Medicine

Authors

Semple F, MacPherson H, Webb S, Cox SL, Mallin LJ, Tyrrell C, Grimes GR, Semple CA, Nix MA, Millhauser GL, Dorin JR

Source Repository

Gene Expression Omnibus (GEO)

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