github link
Accession IconGSE25319

Gene transcription profiles showing early systemic response to E. coli (k2bh2) infection in bovine liver

Organism Icon Bos taurus
Sample Icon 53 Downloadable Samples
Technology Badge Icon Affymetrix Bovine Genome Array (bovine)

Submitter Supplied Information

Description
We studied the response to infection and associated perturbations to the bovine livers normal function by examining gene transcription data from liver biopsies collected following an E. coli infection in the udder of primiparous dairy cows. This is the first study to examine gene transcription responses to systemic infection by the E. coli bacterium in dairy cows. First, we verified that the inoculation protocol resulted in systemic infection in the cows. This was done based on records on three clinical symptoms: body temperature and amount of E. coli bacteria and leukocytes in milk samples. Second, we examined gene transcription patterns underlying the clinical traits. Gene transcription levels at times of peak values for the clinical traits were estimated in the liver to study indications of an acute phase response to systemic E. coli infection in the cows. Finally, we compared gene transcription responses to E. coli infection and lipopolysaccaride (LPS) inoculation.
PubMed ID
Total Samples
54
Submitter’s Institution

Samples

Show of 0 Total Samples
Filter
Add/Remove
Accession Code
Title
Sex
Specimen part
Time
Processing Information
Additional Metadata
No rows found
Loading...