Expression data from MMP-8 wild type and KO mice with or without arthritis

Rheumatoid arthritis is an autoimmune disease in which joint inflammation lead to progressive cartilage and bone destruction. Matrix metalloproteinases (MMP) implicated in homeostasis of extracellular matrix (ECM) play a central role in cartilage degradation. The aim of this study was to investigate the role of MMP-8 (collagenase-2) suppression in the K/BxN serum-transfer arthritis model.

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García S, Forteza J, López-Otin C, Gómez-Reino JJ, González A, Conde C