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Accession IconGSE22263

Effect of 52 weeks of chronic exposure to TCDD AND PCB126 on hepatic gene expression

Organism Icon Rattus norvegicus
Sample Icon 15 Downloadable Samples
Technology Badge Icon Affymetrix Rat Genome U34 Array (rgu34a)

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Description
This study investigates the effects of the aryl hydrocarbon receptor (AhR) ligands TCDD and PCB126 on hepatic gene expression in female sprague dawley rats. Rats were treated with toxicological equivalent doses of TCDD (100ng/kg/day) (Toxic equivalence factor (TEF) = 1.0), PCB126 (30ng, 300ng or 1000ng/kg/day) (TEF = 0.1) or a vehicle control of corn oil:acetone (99:1) 5 days a week for 52 weeks.
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