Gene expression profile of human ovarian cancer cell lines in vitro

We have previously described how TNF-, IL-6, CXCR4 and the CXCR4 ligand CXCL12 are expressed by human ovarian cancer cells in vitro. By comparing four ovarian cancer cell lines with varying levels of constitutive TNF- production we found that CXCR4, CXCL12, TNF- and IL-6 were linked in an autocrine network in malignant cells that had an effect on tumour growth and angiogenesis in one xenograft model of ovarian cancer.

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