Expression analysis in yeast model of Huntington's disease (HD)

GSE18644

Saccharomyces cerevisiae

15 Downloadable Samples

Affymetrix Yeast Genome S98 Array (ygs98)

Submitter Supplied Information

Description

Expressing a mutant fragment of huntingtin (Htt) in yeast produces several HD-relevant phenotypes. We used microarrays to study global change in expression induced by this mutant htt fragment.

PubMed ID

21044956

Publication Title

Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity.

Total Samples

Submitter’s Institution

University of Leicester

Authors

Tauber E, Miller-Fleming L, Mason RP, Kwan W, Clapp J, Butler NJ, Outeiro TF, Muchowski PJ, Giorgini F

Source Repository

Gene Expression Omnibus (GEO)

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