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Accession IconGSE18444

Genome-wide transcriptional profiling of NF1-haploinsufficiency in human: Coriell kindred

Organism Icon Homo sapiens
Sample Icon 18 Downloadable Samples
Technology Badge IconSentrix Human-6 Expression BeadChip

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Description
Neurofibromatosis type 1 (NF1) is a common monogenic tumor-predisposition disorder that arises secondary to mutations in the tumor suppressor gene NF1. Haploinsufficiency of NF1 fosters a permissive tumorigenic environment through changes in signalling between cells; however, the intracellular mechanisms for this tumor-promoting effect are less clear. We hypothesized that the genetic effects of NF1-haploinsufficiency may be discerned by comparison of genome-wide transcriptional profiling in somatic, non-tumor cells (LCLs) from NF1-affected and unaffected individuals.
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