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Accession IconGSE18157

Gene expression underlying the effects of biotin deficiency in rat liver, worms and yeast

Organism Icon Saccharomyces cerevisiae, Caenorhabditis elegans, Rattus norvegicus
Sample Icon 17 Downloadable Samples
Technology Badge Icon Affymetrix C. elegans Genome Array (celegans), Affymetrix Rat Genome 230 2.0 Array (rat2302), Affymetrix Yeast Genome 2.0 Array (yeast2)

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Description
Biotin is cofactor of crucial enzymes for intermediary metabolism, and its deficiency affects the transcription of some critical genes of mammalian glucose metabolism. However, the precise mechanisms of biotin starvation on gene expression are unknown. Here we show that metabolic changes ushered by deficiency of this vitamin sets in motion extensive reorganization of carbon metabolism gene expression, consistent across three diverse eukaryotes, that is mediated through a regulatory circuitry at the genome level similar in the three species.
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