Role of zyxin in the tension-induced expression change in endothelial cells

One of the hallmarks in hypertension is a pressure-induced change in endothelial cell phenotype. A cytoskeletal protein zyxin, which was seen to translocate from focal adhesion contacts to the nucleus in response to the increased wall tensionis, mediates the tension-induced endothelial signaling.

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Wójtowicz A, Babu SS, Li L, Gretz N, Hecker M, Cattaruzza M