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Accession IconGSE17257

Expression data of Saccharomyces cerevisiae treated with clioquinol

Organism Icon Saccharomyces cerevisiae
Sample Icon 6 Downloadable Samples
Technology Badge Icon Affymetrix Yeast Genome 2.0 Array (yeast2)

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Description
Clioquinol (CQ or iodochlorhydroxyquin, 5-chloro-7-iodo-8-hydroxyquinoline) is a hydrophobic chelator of copper, zinc, and iron. It was extensively used as an antibiotic for the treatment of diarrhea and skin infection in the mid-1900s, but then withdrawn because it was reported to be associated with subacute myelo-optic neuropathy (SMON) in Japan. Interest in this drug was recently revived as it was shown that CQ specifically kills cancer cells and significantly decreases A level. Nevertheless, the underlying mechanisms of CQs drug effects and side effects are still unclear.
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