Parasite strain-specific pathogenesis in murine infections with Trypanosoma brucei

Different strains of T. brucei induce different degrees of pathology in infected animals, and TREU927-infected mice display greater splenomegaly and anaemia than 247-infected mice. The analysis of differential host gene expression in infected spleens has allowed the identification of which pathways or processes are crucial in determining the progression of disease, for example IL10, LXR/RXR activation and alternative macrophage activation.

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Morrison LJ, McLellan S, Sweeney L, Chan CN, MacLeod A, Tait A, Turner CM