IL-4 Receptor a Subunit Deficiency Alleviates Murine Intestinal Inflammation In Vivo through the Enhancement of Intestinal Mucosal Barrier Function

In the present study we investigate the role of IL-4 receptor a subunit in intestinal inflammation using DSS-induced colitis model. Our finding suggest that IL-4Ra deficiency enhances intestinal mucosal barrier function through the upregulation of NOX1-dependent ROS production, thereby suppressing the development of intestinal inflammation.

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Hertati A, Hayashi S, Ogawa Y, Yamamoto T, Kadowaki M