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Accession IconGSE15745

Abundant Quantitative Trait Loci for CpG Methylation and Expression Across Human Brain Tissues

Organism Icon Homo sapiens
Sample Icon 584 Downloadable Samples
Technology Badge IconIllumina humanRef-8 v2.0 expression beadchip

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Description
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We describe a set of integrated experiments designed to investigate the effects of common genetic variability on DNA methylation, mRNA expression and microRNA (miRNA) expression in four distinct human brain regions. We show that brain tissues may be readily distinguished based on methylation status or expression profile. We find an abundance of genetic cis regulation mRNA expression and show for the first time abundant quantitative trait loci for DNA CpG methylation. We observe that the largest magnitude effects occur across distinct brain regions. We believe these data, which we have made publicly available, will be useful in understanding the biological effects of genetic variation.
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1658
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