Effect of imatinib on FIP1L1-PDGFRA-expressing EOL1 cells

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GSE15237

Homo sapiens

2 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

The Eol1 cell line has been derived from a patient with chronic eosiniphilic leukemia. Eol1 cells express the FIP1L1-PDGFRalpha oncogene. Inhibition of FIP1L1-PDGFRalpha with imatinib mesylate (Glivec) blocks proliferation and survival of the cells. We performed microarray expression analysis to identify genes specifically regulated by FIP1L1-PDGFRalpha using imatinib-treated cells as baseline. The list of regulated genes was consistent with the activation of STAT trancription factors by FIP1L1-PDGFRA.

PubMed ID

20215436

Publication Title

Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data.

Total Samples

Submitter’s Institution

Universit catholique de Louvain

Authors

Essaghir A, Toffalini F, Knoops L, Kallin A, van Helden J, Demoulin JB

Source Repository

Gene Expression Omnibus (GEO)

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