Expression data from adult rat subventricular zone cells

Transforming growth factor (TGF)-1 is a multifunctional cytokine regulating a number of physiological and patho-physiological processes in the adult brain. Its expression is elevated during neurodegeneration, which is associated with reduced levels of neurogenesis. We have postulated that TGF-1 might be one of the crucial factors involved in limiting neurogenesis in the diseased brain.

2