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Accession IconGSE14489

Gene profiling of v-Src transformed primary chicken cells

Organism Icon Gallus gallus
Sample Icon 23 Downloadable Samples
Technology Badge Icon Affymetrix Chicken Genome Array (chicken)

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Description
Cell transformation by the Src tyrosine kinase is characterized by extensive changes in gene expression. To describe these changes, investigators have relied extensively on the study of immortalized rodent cell lines or heterogeneous tumor samples that limit the identification of differentially expressed genes or may not represent the full spectrum of biological processes regulated during transformation. In this study, we took advantage of transformation-deficient and temperature sensitive mutants of the Rous sarcoma virus to characterize the patterns of gene expression in two types of primary cells, namely chicken embryo fibroblasts (CEF) and chicken neuro-retinal (CNR) cells.
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