Effect of DMHF (2,5-dimethyl-4-hydroxy-3(2H)-furanone) inhalation on gene expression in Rat brain

Background: 2,5-Dimethyl-4-hydroxy-3(2H)-furanone (DMHF) is one of the major odor compounds generated by the Maillard reaction. We previously reported that the inhalation of DMHF decreased systolic blood pressure via the autonomic nervous system in rats. The autonomic nervous system is also closely related to appetite regulation. The present study investigated the effects of DMHF on dietary intake and gene expression.

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Yokoyama I, Nakai Y, Suzuki Y, Ohata M, Komiya Y, Nagasao J, Arihara K