The role of methyl-CpG-binding domain protein-2 (MBD2) in colonic inflammation [series 1]

GSE134280

Mus musculus

27 Downloadable Samples

Illumina MouseWG-6 v2.0 expression beadchip

Submitter Supplied Information

Description

Mice deficient in MBD2 (Mbd2-/-) were treated with 2% dextran sulfate sodium or normal drinking water for 6 continuous days. A single cell suspension of colon lamina propria and epithelium was isolated, with monocytes (CD11b+ Ly6CHi, MHC-II+/-), macrophages (CD11b+ Ly6C-MHC-II+), cDC2s (CD11b- CD11c+ CD103+) and epithelial cells (CD45- EpCAM+) purified by FACS.

PubMed ID

32117307

Publication Title

The Methyl-CpG-Binding Protein Mbd2 Regulates Susceptibility to Experimental Colitis via Control of CD11c<sup>+</sup> Cells and Colonic Epithelium.

Total Samples

Submitter’s Institution

Centre for Immunity, Infection and Evolution

Authors

Jones GR, Brown SL, Phythian-Adams AT, Ivens AC, Cook PC, MacDonald AS

Source Repository

Gene Expression Omnibus (GEO)

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