Mechanism and transcriptional program of YB-1 in breast cancer cell lines.

GSE13410

Homo sapiens

9 Downloadable Samples

Affymetrix Human Exon 1.0 ST Array [probe set (exon) version (huex10st), Affymetrix Human Human Exon 1.0 ST Array (huex10st)

Submitter Supplied Information

Description

YB-1 controls epithelial-mesenchymal transitions by restricting translation of growth-related mRNAs and enabling expression of EMT-inducing transcription factors. We used microarrays to characterize the direct transcriptional and indirect translational regulation of mRNAs by exogenous YB-1 in breast cancer cell lines.

PubMed ID

19411069

Publication Title

Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition.

Total Samples

Submitter’s Institution

GenomeDx Biosciences Inc

Authors

Evdokimova V, Tognon C, Ng T, Ruzanov P, Melnyk N, Fink D, Sorokin A, Ovchinnikov LP, Davicioni E, Triche TJ, Sorensen PH

Source Repository

Gene Expression Omnibus (GEO)

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