(AKR/J x PyMT)F1 versus (DBA/2J x PyMT)F1 tumor expression data

F1 hybrids from (AKR/J x FVB/NJ) and (DBA/2J x FVB/NJ) outcrosses display a 20-fold difference in mammary tumor metastatic capacity, due to differences in inherited polymorphisms. Expression studies were performed to determine whether polymorphism-driven gene expression signatures predictive of outcome could be generated from mouse tumor tissues

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Lukes L, Crawford NP, Walker R, Hunter KW