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Accession IconGSE12363

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

Organism Icon Homo sapiens, Mus musculus
Sample Icon 32 Downloadable Samples
Technology Badge Icon Affymetrix Human Promoter 1.0R Array (hsprompr), Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2)

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Description
We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL.
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