Cellular and Molecular Changes in Psoriasis Lesions Induced by Ustekinumab: Distinct Differences in Responders vs. Non-Responders

A gene expression profiling sub-study was conducted in which skin biopsy samples (n=192) were collected for RNA extraction and hybridization to microarrays from patients with moderate-to-severe psoriasis who participated in ACCEPT, an IRB-approved Phase 3, multicenter, randomized trial.

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Brodmerkel C, Li K, Garcet S, Hayden K, Chiricozzi A, Novitskaya I, Fuentes-Duculan J, Suarez-Farinas M, Campbell K, Krueger JG