Gene expression in primary acute lymphoblastic leukemia (ALL) associated with methotrexate treatment response

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GSE10255

Homo sapiens

158 Downloadable Samples

Affymetrix Human Genome U133A Array (hgu133a)

Submitter Supplied Information

Description

Genome-wide assessment of gene expression in primary acute lymphoblastic leukemia cells was performed to identify genomic determinants of MTXs antileukemic effects. Reduction of circulating leukemia cells after in vivo methotrexate treatment served as a measure MTX's antileukemic effects.

PubMed ID

18416598

Publication Title

In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile.

Total Samples

161

Submitter’s Institution

St.Jude Children's Research Hospital

Authors

Sorich MJ, Pottier N, Pei D, Yang W, Kager L, Stocco G, Cheng C, Panetta JC, Pui CH, Relling MV, Cheok MH, Evans WE

Source Repository

Gene Expression Omnibus (GEO)

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