AhR activation by TCDD in the ET, cortical epithelial cell line

GSE10168

Mus musculus

12 Downloadable Samples

Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2)

Submitter Supplied Information

Description

Over activation of the aryl hydrocarbon receptor (AhR) by TCDD results ampng other phenotypes in severe thymic atrophy accompanied by immunosuppression. The link between thymic atrophy, skewed thymocyte differntiation and immunosuppression is still not fully resolved. This study investigates the TCDD elicted exprssion changes in the ET, cortical thymus epithelial cell line.

PubMed ID

18691609

Publication Title

Promoter analysis of TCDD-inducible genes in a thymic epithelial cell line indicates the potential for cell-specific transcription factor crosstalk in the AhR response.

Total Samples

Submitter’s Institution

Institute for Environmental Research

Authors

Frericks M, Burgoon LD, Zacharewski TR, Esser C

Source Repository

Gene Expression Omnibus (GEO)

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