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Accession IconGSE100443

RNA Expression Profiling of CD8+ T Cell-Enriched Peripheral Blood Mononuclear Cells from Potentiated Sulfonamide-Treated Patients with a Range of Lymphocyte Cytotoxicity Phenotypes

Organism Icon Homo sapiens
Sample Icon 20 Downloadable Samples
Technology Badge Icon Affymetrix Human Transcriptome Array 2.0 (hta20)

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Description
Hypersensitivity reactions are rare, but potentially severe adverse effects of sulfonamide antibiotics. Increased in vitro toxicity of lymphocytes, primarily CD8+ T cells, to sulfonamide drug metabolites as been proposed as a marker for sulfonamide hypersensitivity, but the mechanisms underlying this marker are unknown.
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