Role of heparan sulphate in mouse brain development.

Heparan sulphates (HS) are polysaccharides found on all animal cells whose function is regulated by sulphation. One of the roles of HS is to regulate cell signalling pathways which instruct gene expression. In this study we acquired transcriptomes of telencephalic midline tissue from wild-type embryos or mutant embryos lacking specific enzymes, Hs2st or Hs6st1, involved in the addition of sulphate to HS.

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