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Accession IconDRP003826

A distinct subset of CD25 negative T-follicular regulatory cells localize in the germinal centers

Organism Icon Mus musculus
Sample Icon 12 Downloadable Samples
Technology Badge IconIon Torrent Proton

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Description
We describe GC-Tfr, a population of CD25 negative Foxp3 positive CXCR5hiPD1hiBCL6hi T-follicular regulatory cells that preferentially localise in the germinal centers. Male C57BL/6 Foxp3-DTR-GFP reporter mice were vaccinated with NP-Ova in Alum and 7 days later cells sorted before RNA-sequencing. Analysis revealed that GC-Tfr have a gene expression pattern equidistant between Tregs and Tfh, but fundamentally retain their suppressive characteristics as regulatory cells.
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